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NFL Week 6 Betting Guide: Football Odds, Predictions & Picks

Six weeks into the season is usually when teams start to distance themselves from the pack. When you’re looking at your NFL Week 6 betting options, there’s plenty to choose from. Our prime time slate is again solid, with the defending Super Bowl champion Philadelphia Eagles traveling to New Jersey to face off against their NFC East rival New York Giants. When the books released their NFL betting odds for this week back in May, they gave the Eagles a three-point advantage. Will it stick? We’ll take a look at it.

Sunday night gives second-year quarterback Patrick Mahomes his first shot at Tom Brady when the Kansas City Chiefs travel to Foxboro to take on the New England Patriots. New England has opened as a touchdown favorite in that one.

For whatever reason, the NFL schedule makers have decided that Monday Night Football games should no longer be terrible. For the two previous weeks, they’ve been solid matchups and MNF delivers once again as the San Francisco 49ers face off against the Green Bay Packers at Lambeau Field. The Pack have opened as a four-point favorite.

We’ve also got all the opening NFL odds for the Sunday games as well, with plenty of odd-ball contests for you to toss your money at. With the exception of a few divisional match ups, there’s plenty of rare, cross-conference games to look at when considering your NFL betting options.

NFL Week 6 Betting Guide:

Thursday Night Football Odds (Oct. 11)

Philadelphia Eagles at New York Giants
Kickoff: 8:20 p.m. EST
Broadcast: FOX, NFL Network, Amazon Prime
Opening Line: Eagles -3
Total: 45

Are the Giants due for a bounce-back season under first-year coach Pat Shurmur? I definitely think so and this would be a great game to make some real noise for New York. Does that mean I’m suggesting you pick them to win? Nope.

Unless there’s some kind of drastic injury leading into this game, I don’t see this line moving much. If anything, it may tick up another half-point Philly’s way to -3.5.

Here’s something you may want to consider if you’re thinking of jumping on this one early. The Eagles are coming in off a huge game against the Minnesota Vikings on a short week’s rest. They could very well be beat up. The Giants will roll in after a tough contest of their own, playing at the Carolina Panthers, but not one with nearly as much as stake.

Sunday, Oct. 14

Arizona Cardinals at Minnesota Vikings

Line: Vikings -10.5

Total: 43

Los Angeles Chargers at Cleveland Browns

Line: Chargers -1.5

Total: 46

Chicago Bears at Miami Dolphins

Line: Bears -3

Total: 44.5

Carolina Panthers at Washington Redskins

Line: Redskins -2

Indianapolis Colts at New York Jets

Line: Jets -2.5

Total: 45.5

Pittsburgh Steelers at Cincinnati Bengals

Line: Bengals -2.5

Total: 54.5

Tampa Bay Buccaneers at Atlanta Falcons

Line: Falcons -3.5

Total: 57.5

Seattle Seahawks at Oakland Raiders

Line: Seahawks -3

Total: 47.5

Buffalo Bills at Houston Texans

Line: Texans -8.5

Los Angeles Rams at Denver Broncos

Line: Rams -7

Total: 52.5

Jacksonville Jaguars at Dallas Cowboys

Line: Jaguars -2

Baltimore Ravens at Tennessee Titans

Line: Ravens -1.5

Total: 42

Sunday Night Football Odds (Oct. 14)

Kansas City Chiefs at New England Patriots

Line: Patriots -3.5

Total: 58.5

New England will come into this game with 10 days rest after facing the Indianapolis Colts on Thursday Night football the week before. As excited as everyone is about Mahomes taking over for Alex Smith with the Chiefs this season, I’m a little more hesitant to jump on that bandwagon just yet. I think this line is solid and, with the extra prep time, New England is going to be tough to hang with at Gillette. It may move up to -7.5.

Monday Night Football Odds (Oct. 15)

San Francisco 49ers at Green Bay Packers

Line: Packers -9.5

Total: 46.5

As much as has been made about how much Aaron Rodgers hates the 49ers for picking Alex Smith over him in the 2005 NFL Draft, that hasn’t factored much into the final scores. Since Rodgers took over the Packers in 2008, he’s had seven shots against San Francisco and lost four of them. In fact, those four losses all came in a row from 2012-2014, two of them were in the playoffs and one of those postseason losses was at Lambeau Field.

NFL week 6 betting

San Francisco and Green Bay haven’t faced off since 2015, when Rodgers finally ended his four-game losing streak with a 17-3 victory in Santa Clara. This 49ers team, led by quarterback Jimmy Garoppolo and head coach Kyle Shanahan, is going to be a whole different animal.

While Green Bay is favored by four, that line might move based on what happens in the first five weeks of the season. I’ve made it clear that I think Mike McCarthy is one of the worst head coaches in the league and the Pack could come into this game anywhere from 5-0 to 3-2. I expect the 49ers to be somewhere in the same range, most likely 4-1. This game could be a pick-em by kickoff. If you like the 49ers, and there are plenty of reasons to, you might want to jump on this one now.

NFL Week 6 Betting Guide: Football Odds, Predictions & Picks
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NFL Week 6 Betting Guide: Football Odds, Predictions & Picks
NFL Week 6 betting guide for new and intermediate sports bettors, including NFL Week 6 odds, predictions and NFL picks made by out experts.

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