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Home » Blog » San Diego Padres at San Francisco Giants Matchup 09/25/18
MLB

San Diego Padres at San Francisco Giants Matchup 09/25/18

GMS Previews
Last updated: November 9, 2025 9:18 am
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6 Min Read
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John Hefti-USA TODAY Sports

The San Diego Padres are ready to face their in-state rival San Francisco Giants at AT&T Park. Fox Sports San Diego is in line to televise the matchup and the opening pitch will be at 10:15 p.m. ET.

Contents
  • San Diego Padres vs. San Francisco Giants Odds
  • San Diego Padres vs. San Francisco Giants Prediction
  • Notes

San Diego Padres vs. San Francisco Giants Odds

Oddsmakers are listing San Diego (+110) as the underdog to San Francisco (-120). The total sits at 7.5 runs and gamblers can take the over for even money (+100) or the under for -120. Bettors can also wager on the game’s runline with the most recent odds sitting at Padres +1.5 runs (-190) and Giants -1.5 runs (+165).

The Padres have gone 63-94 SU this year and are 74-82 against the spread (ATS). They’ve lost 13.9 units for moneyline bettors and 29.9 units ATS. San Diego is 3-4 ATS over its last seven games and the over has hit in five of those seven. The Giants, on the other hand, are 72-85 SU and 85-71 ATS. They’ve lost 4.3 units for bettors taking the moneyline while earning 8.4 units ATS. San Francisco has covered the spread four times in its last seven games and the total has gone over in five of those seven.

Giants games have an over/under record of 66-84-6 in 2018. The Padres have an over/under record of 76-74-6.

The left-handed Robbie Erlin will get the start for San Diego. Erlin is 4-7 with a 4.33 ERA and 84 strikeouts. He’s 1-0 with seven strikeouts and a 5.06 ERA against San Francisco this year.

The Giants are sending righty Chris Stratton (10-10, 4.88 ERA) to the mound. Stratton has 106 strikeouts and 47 walks to his name, as well as a 1.37 WHIP. Stratton is 1-2 with nine strikeouts and a 3.94 ERA across three starts against San Diego this year.

San Diego’s pitching staff allowed 4.8 runs per game and its starting pitchers own a 5.18 ERA, 1.47 WHIP and 7.39 K/9. The bullpen has logged an ERA of 3.58, along with a WHIP of 1.47 and a K/9 of 10.22.

Padres hitters have slashed .235/.299/.380 on their way to 3.8 runs scored per game this season, including 3.6 runs per game against divisional foes and 4.0 per game over the team’s last five outings (3-2 SU).

San Diego’s offense has been fueled by first baseman Eric Hosmer and shortstop Freddy Galvis, who have combined to swat 30 home runs. Hosmer is slashing .250/.315/.394 with 17 home runs, 65 RBIs and 71 runs scored, while Galvis has a .241 average with 13 homers, 66 RBIs and 60 runs scored.

In the home-team dugout, San Francisco’s pitching staff has allowed 4.2 runs per game overall in 2018. Its starters have an ERA of 3.97, a WHIP of 1.31 and a strikeouts-per-nine of 7.1. The bullpen has a 3.71 ERA, 1.27 WHIP and 8.9 K/9. In 71 games against NL West foes, Giants starters have an ERA of 3.77 and the bullpen’s ERA is 3.15.

The San Francisco offense has put up 3.8 runs per outing, including 3.6 per game against divisional foes and 2.6 per game over its last five. The team has a slash-line of .223/.280/.297 over its last five matchups and is 0-5 SU during that span.

Shortstop Brandon Crawford and right fielder Andrew McCutchen have led the Giants’ batters this year. Crawford is slashing .256/.322/.398 with 14 home runs, 54 RBIs and 61 runs scored, and McCutchen’s line is .255/.357/.415 with 15 homers, 55 RBIs and 65 runs.

The Padres have gained 3.2 units and are 55-48 ATS when facing a righty starter this season. The over has cashed in 45 of those games, compared to 54 that’ve gone under against right-handed starting pitchers. On the other hand, the Giants have netted 1.3 units and are 33-27 ATS when facing a lefty starter. The over’s hit in 28 of those games, compared to 30 that went under the total.

San Diego Padres vs. San Francisco Giants Prediction

Predictions: SU Winner – Giants, ATS Winner – Padres, O/U – UNDER

Click Here to Start Betting Today!

Notes

Betting Trends

The over has hit in five of San Francisco’s last seven games.

San Francisco has posted 19.5 Runs + Hits + Errors per game over its last 10 outings and 18.2 over its last five.

The Padres have hit 11 home runs in their last 10 games, including six over their last five.

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TAGGED:BaseballMLBSan Diego PadresSan Francisco Giants
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