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Reading: San Francisco Giants vs. St. Louis Cardinals Matchup 09/22/18
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Home » Blog » San Francisco Giants vs. St. Louis Cardinals Matchup 09/22/18
MLB

San Francisco Giants vs. St. Louis Cardinals Matchup 09/22/18

GMS Previews
Last updated: November 9, 2025 10:00 am
GMS Previews
5 Min Read
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Jeff Curry-USA TODAY Sports

The St. Louis Cardinals are set to host the San Francisco Giants at Busch Stadium. This NL matchup will be nationally broadcasted on Fox and the game gets underway 1:05 p.m. ET.

Contents
  • San Francisco Giants vs. St. Louis Cardinals Odds
  • San Francisco Giants vs. St. Louis Cardinals MLB Tip
  • Notes

San Francisco Giants vs. St. Louis Cardinals Odds

St. Louis (-170) is hosting this one as the favorite against San Francisco (+160) and oddsmakers have set the Over/Under for this game at 8 runs (+100 for the over and -120 for the under). The game’s runline odds stand at -135 for taking the Giants +1.5 runs and +115 for the Cardinals -1.5.

The Giants are 72-82 SU and are 84-69 against the spread (ATS). They’ve lost 1.3 units for moneyline gamblers, despite having gained 10.1 units ATS. San Francisco has covered the spread six times in its last seven games and the under has hit in five of those seven. The Cardinals, on the other hand, are 85-69 SU and 80-73 ATS. They’ve gained 3.8 units for bettors taking the moneyline and 6.5 units ATS. St. Louis has a 3-4 ATS record over its last seven outings and the over has cashed in five of those seven.

Cardinals games have an over/under record of 72-75-6 in 2018. San Francisco has been a great under bet with a total record of 63-84-6.

Dereck Rodriguez will get the start for San Francisco. Rodriguez is 6-4 with a 2.30 ERA and 86 strikeouts. He’s 0-0 with a 2.70 ERA against St. Louis this year.

The Cardinals will put the ball in the right hand of Adam Wainwright (2-3, 3.72 ERA, 1.55 WHIP), who has 27 strikeouts and 17 walks. Wainwright has yet to face the Giants this year and only made one start against them in 2017 (1-0, 1.42 ERA and six strikeouts across 6.1 innings).

St. Louis’ pitchers have given up 4.2 runs per game overall this season as a unit. Its starters have an ERA of 3.46, a WHIP of 1.26 and a strikeouts-per-nine of 8.2. The bullpen has a 4.31 ERA, 1.45 WHIP and 8.4 K/9.

St. Louis’ hitters have produced 4.7 runs per contest, including 5.7 per game over its last 10 games and 6.4 per game over their last five. The team has a slash-line of .279/.358/.465 over its last five matchups and is 4-1 SU during that span.

The Cardinals’ hitters have been led by outfielder Marcell Ozuna and first baseman Jose Martinez. Ozuna is slashing .281/.324/.435 with 22 home runs, 85 RBIs and 67 runs scored, while Martinez is hitting .304 with 16 homers, 80 RBIs and 61 runs.

In the visiting dugout, San Francisco’s pitching staff allowed 4.2 runs per game and its starters own a 3.95 ERA, 1.30 WHIP and 7.17 K/9. The bullpen has an ERA of 3.61, along with a WHIP of 1.30 and a K-per-9 of 8.88.

The Giants offense has slashed .241/.305/.373 on its way to 3.8 runs scored per game this year, including 2.6 runs per game over the team’s last 10 games and 3.6 per game over the team’s last five outings (2-3 SU).

San Francisco’s hitters have been led by shortstop Brandon Crawford and outfielder Andrew McCutchen. Crawford is slashing .258/.326/.396 with 13 home runs, 52 RBIs and 60 runs scored, while McCutchen (.255/.357/.415) is up to 15 homers, 55 RBIs, 65 runs and 13 stolen bases.

The Giants have lost 2.5 units and are 51-42 ATS when facing a right-handed starting pitcher this year. The over has hit in 35 of those games, compared to 54 that’ve gone under against ies.

San Francisco Giants vs. St. Louis Cardinals MLB Tip

Predictions: SU Winner – Cardinals, ATS Winner – Giants, O/U – OVER

Click Here to Start Betting Today!

Notes

Betting Trends

San Francisco has logged 12 extra-base hits over its last five outings. St. Louis has 18 XBH over its last five.

The Giants have hit four home runs in their last 10 games, including four over their last five.

St. Louis has recorded 22.7 Runs + Hits + Errors per game over its last 10 outings and 25.6 over its last five.

The Cardinals have won four of their last five games SU.

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TAGGED:BaseballMLBSan Francisco GiantsSt Louis Cardinals
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